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September 20, 2025Frontiers in ImmunologyOpen Access

Regulatory T cell therapy for xenotransplantation, what perspectives?

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Authors

RPRaphaël PorretELErica LanaAMAntonio Mancarella

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Overview

This review discusses regulatory T cell interventions for reducing immunosuppression in xenotransplantation, indicating potential novel approaches.

Key Points

  • Regulatory T cell therapy may reduce the burden of immunosuppression in pig-to-human transplants, improving outcomes.
  • Recent advancements in xenotransplantation reveal continued risks of rejection despite advanced immunosuppressive regimens.
  • Exploring genetically modified Tregs presents a unique opportunity for enhancing compatibility of pig organs with human patients.
  • Humanizing pigs with human leukocyte antigens may facilitate tolerance, advancing xenotransplantation therapies.

Cite This Study

Porret et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa67762https://doi.org/10.3389/fimmu.2025.1685682
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