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September 20, 2025Clinical and Translational DiscoveryOpen Access

Translational values of tissue‐resident memory T cells in chronic inflammation and cancer

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Authors

WDWenfeng DuanXWXiangdong Wang

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Overview

Observational analysis reveals the role of tissue-resident memory T cells in inflammation and cancer, suggesting a pathway for immunotherapy.

Key Points

  • Tissue-resident memory T cells actively participate in both chronic inflammation and cancer progression.
  • Pro-inflammatory cytokine IL-17 produced by TRM T cells plays a significant role in tissue damage and immune response.
  • High-resolution techniques like single-cell RNA sequencing uncover unique T-cell subsets linked to disease mechanisms.
  • Understanding TRM T-cell dynamics may lead to better diagnostics and therapeutic targets in cancer treatment.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa678f6https://doi.org/10.1002/ctd2.70078
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