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September 20, 2025Journal of Biological ChemistryOpen Access

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

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Authors

MHMian HuangACAbbie CelnikerRCRezvan Chitsazi

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Overview

Research identifies receptor activation dynamics of CCL27 and CCL28 in epithelial tissues, suggesting new therapeutic possibilities.

Key Points

  • Deleting two residues from CCL27 generates a CCR10 antagonist, underscoring their importance in receptor interactions.
  • Engineered chemokines showed contrasting activation of CCR10, highlighting distinct functional roles of CCL27 and CCL28.
  • AlphaFold modeling clarified differences in receptor binding pockets, revealing the unique adaptability of chemokines.
  • CCL28's high affinity for glycosaminoglycans suggests significant roles in mucosal immunity and tissue retention.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa679aahttps://doi.org/10.1016/j.jbc.2025.110736
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