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September 20, 2025PLoS neglected tropical diseasesOpen Access

Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection

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Authors

LSLeandro S. SilvaBMBrian G. MonksCFCatherine S. Forconi

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Overview

Investigating interleukin-10's effects on parasitemia and inflammation in chronic Plasmodium infections, revealing immune regulation.

Key Points

  • Interleukin-10 plays a protective role in limiting immune-mediated pathology during chronic Plasmodium infection.
  • Mice without humoral immunity show a significant immune response when IL-10 signaling is disrupted, indicating its importance.
  • Analysis of IL-10 levels in infected mice highlights the role of CD4+ T cells in maintaining immune balance against parasites.
  • Blocking IL-10 signaling leads to increased parasitemia and mortality in chronic Plasmodium-infected mice.

Cite This Study

Silva et al. (2025) studied this question.

synapsesocial.com/papers/68d46ab431b076d99fa679d9https://doi.org/10.1371/journal.pntd.0013554
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