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September 20, 2025Chinese Medical JournalOpen Access

Multimodal profiling identifies CD4+CXCR5+PD-1– Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma

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Authors

SYSisi YuFujian Medical UniversityHKHao KongNorthwest A&F UniversityHLHuaichao LuoSichuan Cancer Hospital

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Implication

Observational analysis reveals CD4+ Tfh cells as predictive biomarkers for treatment response in diffuse large B-cell lymphoma, indicating potential for improved patient outcomes.

Key Points

  • CD4+CXCR5+PD-1– Tfh cells were linked to better overall survival, suggesting their prognostic value in diffuse large B-cell lymphoma.
  • Analysis utilized single-cell RNA sequencing and multiplex immunohistochemistry, uncovering immune landscape changes across treatment stages.
  • In vivo validations in mouse models demonstrated the immune dysfunction in relapsed DLBCL, emphasizing the need for targeted therapies.
  • High infiltration of CD4+CXCR5+PD-1– Tfh cells correlated with positive responses to R-CHOP treatment, indicating their role in effective immunotherapy.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68d46ab431b076d99fa679fbhttps://doi.org/10.1097/cm9.0000000000003826
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