September 20, 2025Open Access

Common origin for effector and regulatory Follicular and Tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer

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Discussion

Integrated analysis reveals tumor-invaded LNs host diverse CD4+ T cell populations, indicating therapeutic targets for immunotherapy.

Tumor-invaded lymph nodes serve as central hubs for activating anti-tumor immune responses, with significant implications for treatment.
Distinct CD4+ T cell subsets were identified, with tumor-invaded LNs enriched in follicular regulatory T cells and memory Tregs.
Integrated TCR-RNA analysis showed significant clonal sharing between tumor-invaded LNs and tumors, highlighting T cell recirculation.
The identification of Treg-Tfr plasticity suggests a potential target for redirecting immunosuppressive responses towards anti-tumor effects.

Tosello et al. (2025) studied this question.

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