A Case of Malignant Melanoma with Bladder Metastasis

Metastatic malignant melanoma involving the urinary bladder is an exceptionally rare finding. We report the case of a man in his mid 70’s who initially presented with stroke-like symptoms. A CT head revealed multiple metastatic lesions with no clear primary origin. Subsequent imaging of the chest, abdomen, and pelvis showed widespread metastases, with lesions in the bladder raising suspicion of it being the primary site. Rigid cystoscopy and transurethral resection of bladder tumour (TURBT) were performed, and histopathology confirmed malignant melanoma. Further investigation supported the diagnosis of metastatic melanoma. The patient was started on corticosteroids, Encorafenib, and Binimetinib. Although he initially responded well to treatment, his disease progressed both clinically and radiologically, and he sadly passed away 10 months after his initial presentation.