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Anti–platelet factor 4 testing for heparin-induced thrombocytopenia: Assessing the indication for its use for quality improvement as a patient safety measure

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Retrospective analysis reveals inadequate adherence to 4T score guidelines in HIT testing, suggesting quality improvement needs.

Only 52.11% of heparin-induced thrombocytopenia tests were indicated by a 4T score of 4 or above, indicating overtreatment.
Clinical characteristics showed that patients with indicated testing had higher platelet counts and a greater percent drop in platelets, all significant at P < .001.
A retrospective analysis of 261 tests found substantial inconsistencies with American Society of Hematology recommendations, necessitating better adherence.
Applying 4T-based decision tools could improve patient safety by reducing unnecessary anticoagulation in patients with low clinical probability.

Bahmad et al. (2025) studied this question.

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