Fluorescence detection method shows high specificity for Mycobacterium tuberculosis DNA, suggesting improved diagnostic capabilities.
We report the fluorescence detection of the conserved G-quadruplex (GQ) motif in Mycobacterium tuberculosis (MTB) DNA, ensuring high specificity with minimal interference from human and non-MTB DNA sequences. The duplex-to-GQ reliable conformational polymorphism (GQ-RCP) enables its application in amplification-compatible MTB detection, offering a platform for precise diagnostic assays.
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