Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 17, 2025International Journal of Innovative Technologies in Social ScienceOpen Access

Current Perspectives on the Management of Acute Graft-Versus-Host Disease in Pediatric Transplantation

View Full Paper
Ask AI
Bookmark
Share

Authors

JPJulia Prabucka-MarciniakMBMichał BerezaMDMateusz Dembiński

Discussion

Loading...

Member takes

Overview

This narrative review examines the treatment interventions and unique immunological factors in pediatric patients with graft-versus-host disease, suggesting a need for tailored protocols.

Key Points

  • Significant advancements in understanding acute graft-versus-host disease have been made, but gaps in pediatric care remain.
  • Current prophylaxis strategies include calcineurin inhibitors with methotrexate, while novel agents show promise for treatment.
  • A comprehensive systematic search identified literature to synthesize data on GVHD management in patients aged 18 or younger.
  • The clear age-related differences in GVHD risk call for pediatric-specific research to improve treatment outcomes.

Cite This Study

Prabucka-Marciniak et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa690c4https://doi.org/10.31435/ijitss.3(47).2025.3734
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SPECIAL CONSIDERATIONS IN THE DIAGNOSIS AND MANAGEMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE IN PEDIATRIC PATIENTS2025
  2. 2Pediatric Cutaneous Graft‐Versus‐Host Disease: Clinical Presentations, Management, and Emerging Therapies2025
  3. 3Gut Microbiome‐Immune Interactions During Pediatric Hematopoietic Cell Transplantation: From Conditioning to <scp>GvHD</scp> Prevention2026
  4. 4Impact of Age on Graft-vs-Host Disease and Overall Survival in Pediatric Hematopoietic Cell Transplant Recipients2025 · 3 citations
  5. 5Risk factors associated with chronic cutaneous graft-versus-host disease following hematopoietic stem cell transplantation: a pediatric cohort2026 · 2 citations