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September 17, 2025CureusOpen Access

Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review

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This comprehensive review discusses GLP-1 RAs in dementia and Parkinson's disease, suggesting new treatment strategies.

GLP-1 receptor agonists may offer a promising disease-modifying approach for neurodegenerative diseases.
Evidence indicates that effective timing of treatment influences the outcomes for Alzheimer's and Parkinson's diseases.
A multi-targeting strategy with GLP-1 RAs has potential to advance treatment options for those with neurodegenerative conditions.
Understanding unwanted side effects like weight loss is crucial for effectively treating at-risk patient populations.

Ibrahim et al. (2025) studied this question.

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