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September 19, 2025Russian Journal of ImmunologyOpen Access

MT1/MT2 melatonin receptors in proinflammatory T helper cell populations

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Authors

ЕКЕ. М. КуклинаIDI. Yu. DanchenkoТБТ. В. Байдина

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Overview

Research shows elevated MT1 and MT2 receptor expression in non-classical Th1-polarized Th17 cells, suggesting melatonin's role in autoimmune diseases.

Key Points

  • Non-classical Th1-polarized Th17 cells express high levels of MT1 and MT2 receptors, indicating potential melatonin sensitivity.
  • The study demonstrated that melatonin activates signaling pathways that may enhance Th17.1 activity and immune response.
  • Investigation of peripheral blood T helper populations highlighted the importance of melatonin receptors in regulating inflammation.
  • Understanding melatonin's mechanisms may provide insights into innovative treatments for autoimmune diseases linked to T cell dysregulation.

Cite This Study

Куклина et al. (2025) studied this question.

synapsesocial.com/papers/68d46cd731b076d99fa69335https://doi.org/10.46235/1028-7221-17120-mmm
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