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September 19, 2025Journal of Surgical OncologyOpen Access

Prognosis and Follow‐Up Recommendations for Subcutaneous and Dermal Leiomyosarcoma: Local Recurrence, Metastasis, and Overall Survival in a Danish Nationwide Cohort of 661 Patients

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Analysis reveals distinct outcomes in leiomyosarcoma types, with implications for follow-up protocols.

Patients with subcutaneous leiomyosarcoma have a higher risk of metastasis at 25% compared to 2.7% for dermal types.
The 10-year overall survival rate is lower for subcutaneous tumors at 56%, as opposed to 64% for dermal tumors.
The study included 661 patients diagnosed with cutaneous leiomyosarcoma in Denmark from 1980 to 2022.
Follow-up for high-risk leiomyosarcoma should include advanced imaging techniques to monitor metastasis.

Abebe et al. (2025) studied this question.

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