Case study shows positive effects of acitretin on linear porokeratosis in a child, suggesting further treatment exploration.
Background. Linear porokeratosis is a rare type of poroceratosis, genetically determined disorder of mevalonate pathway in keratinocytes. It is characterized by high risk of malignant neoplasms (squamous cell carcinoma, basal cell carcinoma, Bowen's disease, melanoma). There is no pathogenetic treatment. Case description. Patient K., 8 years old, had rashes from the first days of life. The rashes have spread all over the body with age. Positive effect in partial regression of rashes was noted after 3 months on acitretin administration at dosage of 10 mg/day. Conclusion. The positive effect of linear porokeratosis management via acitretin has been shown. However, the definition of standard treatment regimens for porokeratosis remains relevant.
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Murashkin et al. (2025) studied this question.
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