This protocol demonstrates regioselective conjugate addition of mercaptopyridine and hydroxypyridine, enhancing functional-group compatibility.
This protocol describes the trifluoroacetic acid-catalyzed regioselective 1,6-conjugate addition of mercaptopyridine and hydroxypyridine to para-quinone methides. The present reactions exhibit superior results in terms of regioselectivity, mild reaction conditions, straightforward workup (no column chromatography purification), and broad substrate scope with good functional-group compatibility. This efficient method enables the synthesis of trisubstituted methanes with pyridone and sulfide core structures.
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Devgunde et al. (2025) studied this question.
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