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This is a Literature Review study.

Epstein-Barr Virus and spontaneous lymphoblastoid cell lines: establishment, molecular characteristics, immune modulation, and therapeutic insight

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Review highlights establishment of spontaneous lymphoblastoid cell lines and their immune modulation, suggesting therapeutic opportunities.

Spontaneous lymphoblastoid cell lines can emerge without viral inoculation, impacting various malignancies.
Clinical findings indicate that cytokines like IL-10 are crucial for the survival of S-LCLs, particularly in autoimmune diseases.
Multiple methodologies, including checkpoint inhibitors and cytokine modulation, establish S-LCLs for better EBV research.
S-LCLs may serve as valuable models for immunotherapy, including CAR T-cells and vaccine platforms in EBV-related diseases.

Adeniran et al. (2025) studied this question.

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Review highlights establishment of spontaneous lymphoblastoid cell lines and their immune modulation, suggesting therapeutic opportunities.