September 20, 2025Clinica Chimica ActaOpen Access

Development and validation of a heme metabolism-related genes signature for diagnosis and immunological characterization of lupus nephritis

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This study identifies diagnostic biomarkers for lupus nephritis based on heme metabolism, suggesting novel immune roles.

The study identifies four diagnostic genes for lupus nephritis, enhancing early diagnosis and treatment options.
Using transcriptomic data, differential analysis identified significant biomarkers with a strong predictive model for lupus nephritis.
Analysis of immune infiltration levels indicates significant increases in immune-related functions amongst lupus nephritis patients.
Consensus clustering analysis reveals two distinct molecular subtypes of lupus nephritis based on diagnostic gene expression.

Wu et al. (2025) studied this question.

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