This review highlights unique reactions involving tropone in natural product synthesis and bioactive molecules.
Tropones are valuable moieties in the synthesis of natural products and bioactive molecules. Tropones have also emerged as fascinating synthetic partners for various (4 + 2)-, (4 + 6)-, (6 + 3)-, (6 + 4)-, (6 + 6)-, (8 + 2)-, and (8 + 3)-cycloaddition reactions as well as functionalization reactions. This review highlights various cycloaddition and functionalization reactions involving tropone building blocks reported since 2014.
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Doraghi et al. (2025) studied this question.
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