This case shows successful heart-lung transplant for a patient with nonischemic cardiomyopathy and thrombosis, addressing cardiogenic shock and severe pulmonary hypertension.
We present a case of a young patient with a history of recurrent venous thromboembolism, stroke status post fibrinolysis, and titin-related dilated cardiomyopathy who developed cardiogenic shock in the setting of decompensated heart failure and concomitant large left ventricular thrombus comprising ∼75% of the cavity. Her shock was managed medically as she was evaluated for surgical heart failure therapies. The patient underwent a combined heart-lung transplant and was discharged after an uneventful postoperative course. This case demonstrates that concomitant end-stage heart failure, large intracardiac thrombus, and severe pulmonary hypertension can be managed successfully with combined heart-lung transplantation.
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Zviman et al. (2025) studied this question.
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