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This is a Experimental Study study.

September 20, 2025

Label-free technique for universal and sequence independent detection of oligonucleotides and nuclease activity.

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This technique achieves sensitivity down to low nanomolar concentrations for DNA and RNA oligonucleotides.
The NucleoProbe method enables universal detection of both endo- and exonuclease activity with improved accuracy.
It represents a significant advancement over traditional fluorescence methods, showing five-fold greater sensitivity.
The approach effectively monitors specific nuclease activity in complex samples, including spiked urine.

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Novel label-free method detects nuclease activity in diverse contexts, highlighting oligonucleotide sensitivity.

Gooran et al. (2025) studied this question.

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