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September 21, 2025Human Genetics and Genomics AdvancesOpen Access

Genome-Wide Association Study Reveals Genetic Mechanisms underlie Eye Disorders and Comorbidities

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Authors

CHChia‐Ni HsiungWCWen‐Cheng ChouCHChih‐Hsiung Hsu

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Overview

Genome-wide association study identifies genetic loci linked to ocular diseases and depression, suggesting shared pathways.

Key Points

  • A strong genetic correlation was found between cataract and depression, indicating a potential shared mechanism.
  • Genome-wide association studies involved over 100,000 individuals, highlighting the significance of genetic factors in eye disorders.
  • Mendelian randomization analysis showed a causal effect of depression on cataract risk through oxytocin signaling pathways.
  • The study connects genetic discovery with clinical implications, paving the way for innovative diagnostic strategies.

Cite This Study

Hsiung et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a21chttps://doi.org/10.1016/j.xhgg.2025.100520
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Also Consider

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  1. 1Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation2026
  2. 2Causal Associations of Glaucoma and Age-Related Macular Degeneration with Cataract: A Bidirectional Two-Sample Mendelian Randomisation Study2024 · 9 citations
  3. 3Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety2024 · 18 citations
  4. 4Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract2024 · 8 citations
  5. 5Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract2025 · 1 citations