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September 22, 2025BMC Emergency MedicineOpen Access

The use of epinephrine in out-of-hospital cardiac arres

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Earlier epinephrine administration increases rates of return of spontaneous circulation and survival.
Patients experiencing successful ROSC received less than 6 mg of epinephrine on average.
Study analyzed 1090 patients who suffered out-of-hospital cardiac arrest and factors influencing outcomes.
Higher doses of epinephrine may lead to poorer neurological outcomes for patients after survival.

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Implication

Observational analysis found that early epinephrine administration improved ROSC and survival rates in OHCA patients, suggesting optimal doses matter.

Cite This Study

Gruebl et al. (2025) studied this question.

synapsesocial.com/papers/68d46fd431b076d99fa6a410 https://doi.org/10.1186/s12873-025-01351-4

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Implication

Observational analysis found that early epinephrine administration improved ROSC and survival rates in OHCA patients, suggesting optimal doses matter.

The use of epinephrine in out-of-hospital cardiac arres

Key Points

Discussion

Implication

Cite This Study

The use of epinephrine in out-of-hospital cardiac arres

Key Points

Discussion

Implication

Cite This Study

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