Clinical and ophthalmological characteristics of corneal regeneration during surgical treatment using the amniotic membrane in dogs

At the present time, reconstructive surgeries are the primary treatment approach, which allow to effectively restore the destroyed area of the stroma, which resulted from deep corneal ulcers. Despite the presented variety of synthetic and biological materials used for the regeneration of the pathological area, further study and search for available, biocompatible materials capable of providing sufficient transparency in the postoperative period remains an urgent task. The article presents the results of using amniotic membrane as a biomaterial for prosthetics of deep corneal ulcers and descemetocele in dogs. The study was carried out at the Department of Diseases of Small Domestic, Laboratory and Exotic Animals of the Federal State Budgetary Educational Institution of Higher Education "ROSBIOTEKH" and the INNOVET Veterinary Clinic. The article presents the results of a study of 26 dogs with ulcerative keratitis, admitted for an appointment over a 9-month period, and describes the results of a study of age, sex and breed predisposition to the development of corneal ulcers. In 11.54% of cases, surgical treatment was performed using amniotic membrane as a biotransplant to ensure successful regeneration of the ulcer defect. As a result of treating deep stromal corneal ulcers, it was possible to achieve regeneration with the formation of leukoma of varying degrees of transparency, preservation of vision and a good cosmetic effect in all described cases. The obtained results of the histological study confirm the effective integration of the amniotic membrane and the prospects of its use in reconstructive and restorative operations for deep ulcer defects.