This research shows how linker design influences degradation efficiency in targeting chimeras, implying potential improvements in selective protein degradation.
Targeting chimeras (TACs), such as PROTACs, LYTACs, AUTACs, and ATTECs, has emerged as a promising strategy for selectively degrading proteins. The linker of the TACs plays a critical role in determining the spatial arrangement, stabilizing the ternary complex, and determining degradation efficiency.
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Duan et al. (2025) studied this question.
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