A new 4-atom linker enables PROTAC development and imaging

Spyros Letsios; Giovana Carrasco; Martin Lee; Mateen Wagiet; Marta Madureira; Marley L. Samways; Zaid Khan; Valerie G. Brunton; Olivera Grubisha; Alison N. Hulme

doi:10.1039/d6cb00127k

January 1, 2025RSC Chemical BiologyOpen Access

A new 4-atom linker enables PROTAC development and imaging

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Key Points

This research aims to explore the impact of a new 4-atom linker on PROTAC development and its imaging capabilities.
Development of a novel 4-atom linker for PROTACs
Assessment of linker effects on biological activity
Imaging techniques employed to visualize PROTACs
The 4-atom linker showed improved biological activity compared to previous linkers
Effective imaging of PROTACs was achieved using the novel linker

Implication

Experimental findings reveal a 4-atom linker enhances biological activity in PROTACs, indicating potential for drug development.

Abstract

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules, emerging as a promising class of drugs.Amongst their structural components, the linker moiety plays a pivotal role in modulating their biological activity and...

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Cite This Study

Letsios et al. (2025) studied this question.

synapsesocial.com/papers/69faa22704f884e66b532c43 https://doi.org/10.1039/d6cb00127k

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A new 4-atom linker enables PROTAC development and imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

A new 4-atom linker enables PROTAC development and imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

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