Analysis of mortality in whooping cough during the period of increase in incidence in 2023–2024

Purpose: to analysis of mortality with pertussis in the Russian Federation during the rise in the incidence of 2023-2024. Material and methods. Medical documents of 15 children who died in 2023-2024. with a posthumous diagnosis of pertussis from 11 regions of the Russian Federation, provided to the Reference Center for Pertussis Monitoring of the FBUN MNIEM named after G.N. Gabrichevsky Rospotrebnadzor. In the reference center, all samples of the sectional material were tested for the presence of B. pertussis DNA using the AmpliPrime ® Bordetella reagent kit and AmpliSenso ® Bordetella multi-FL reagent kit. Results and discussion. Results and discussion. Among the causes of death, the main one is the severe course of pertussis in young children who have morphofunctional immaturity and lack of innate immunological protection against pertussis toxin. The immediate cause of death is damage to the bronchopulmonary system, complicated by the development of a septic process, which led to death. Conclusion. In order to form immunological protection against pertussis in children aged 0-3 months, it is necessary to vaccinate pregnant women who do not have anti-pertussis IgG antibodies. In the early stages of the disease, when respiratory failure appears, it is advisable to use antitoxic methods of therapy.