This synthesis method integrates palladium catalysis for polyfluoroarylation of alkene-tethered carbamoyl chlorides, suggesting novel routes for oxindole production.
We developed a Pd-catalyzed Heck/polyfluoroarylation cascade to synthesize polyfluoroarylated oxindoles with all-carbon quaternary centers from alkene-tethered carbamoyl chlorides. The reaction was extended to a three-component one-pot protocol using amines, BTC,...
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Chen et al. (2025) studied this question.
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