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September 23, 2025Frontiers in Cell and Developmental BiologyOpen Access

Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility

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Authors

ZHZhidan HongWuhan UniversitySHSihan HuangZhejiang A & F UniversityLLLi LiSichuan Academy of Traditional Chinese Medicine

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Overview

This review explores how the piRNA pathway regulates spermatogenesis and its implications for male infertility.

Key Points

  • piRNA pathway is crucial for maintaining germline genome integrity and successful sperm development.
  • Mutations in key piRNA-related genes lead to male infertility conditions like azoospermia and oligozoospermia.
  • The review emphasizes translational strategies targeting piRNA-associated proteins for fertility interventions.
  • Altered piRNA profiles in seminal plasma may serve as non-invasive biomarkers for male fertility issues.

Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/68d4725d31b076d99fa6b50chttps://doi.org/10.3389/fcell.2025.1657744
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Research progress of piRNA as a biomarker for male infertility].2024 · 1 citations
  2. 2Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility2024 · 64 citations
  3. 3How genetic defects in piRNA trimming contribute to male infertility2022 · 24 citations
  4. 4Small RNA molecules in the regulation of spermatogenesis2009 · 160 citations
  5. 5In preprints: illuminating germline dark matter – pachytene piRNA biogenesis and function2026