Conditional disorder in proteins: Functional transitions between order and disorder

B. Gayathri Devi; Niharika Nag; Vladimir N. Uversky; Timir Tripathi

doi:10.1039/d5cc04777c

January 1, 2025Chemical CommunicationsOpen Access

Conditional disorder in proteins: Functional transitions between order and disorder

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Key Points

The study highlights that conditional disorder in proteins can enhance their functional versatility.
Emerging evidence indicates that intrinsically disordered proteins play critical roles in various cellular processes.
The findings suggest a need to revise the classical view of protein structure-function relationships.
Understanding conditional disorder may lead to potential therapeutic innovations targeting protein functionality.

Implication

This research reveals dynamic functional transitions in proteins, suggesting disorder may enhance cellular function.

Abstract

The classical view of protein function based on rigid, well-defined structures is being redefined by the emerging concept of intrinsic disorder. Conditionally disordered proteins (CDPs) represent a subset of cellular...

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Cite This Study

Devi et al. (2025) studied this question.

synapsesocial.com/papers/68d4726431b076d99fa6b6a3 https://doi.org/10.1039/d5cc04777c

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Conditional disorder in proteins: Functional transitions between order and disorder

Key Points

Implication

Abstract

Discussion

Cite This Study

Conditional disorder in proteins: Functional transitions between order and disorder

Key Points

Implication

Abstract

Discussion

Cite This Study

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