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September 23, 2025MedicineOpen Access

Causal relationship between ankylosing spondylitis and multiple sclerosis: Evidence from 2-sample Mendelian randomization

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Authors

RLRui LiuGPGang PengYXYongbing Xiao

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Overview

2-sample Mendelian randomization analysis shows ankylosing spondylitis increases multiple sclerosis risk, indicating shared genetic influences.

Key Points

  • Ankylosing spondylitis is associated with an increased risk of multiple sclerosis, with an odds ratio of 2.18.
  • Mendelian randomization analysis utilized genome-wide association study data, confirming a causal influence of AS on MS.
  • Sensitivity analyses demonstrated the robustness of results, while inverse analysis found no evidence of MS affecting AS.
  • The findings highlight the need for further studies in diverse populations to explore the shared genetic architecture.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4726431b076d99fa6b852https://doi.org/10.1097/md.0000000000044788
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