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Comparative efficacy of iron chelation therapies in thalassemia major: a randomized controlled trial

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DFX showed the greatest reduction in serum ferritin compared to DFO and DFP, indicating its efficacy in iron reduction.
The trial highlighted that DFP exhibited superior cardiac iron clearance, improving treatment options for thalassemia major patients.
Adverse events associated with DFO and DFP/DFX were mild and manageable, emphasizing the relative safety of these therapies.
Therapy personalization based on individual iron deposition profiles could enhance treatment outcomes for patients with thalassemia major.

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Randomized controlled trial compares DFO, DFP, and DFX for reducing iron overload in thalassemia major, suggesting personalized therapy.

Al-Maaroof et al. (2025) studied this question.

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