Sugammadex versus neostigmine for neuromuscular blockade reversal after surgery in pediatric patients: a systematic review and meta-analysis of randomized clinical trials

Puntos clave

• Sugammadex was associated with a faster recovery time to train of four > 0.9, reducing it by over 10 minutes and improving extubation times as well.
• In a pooled analysis of 17 randomized controlled trials, sugammadex showed lower incidences of post-operative nausea vomiting and tachycardia compared to neostigmine.
• Pediatric patients receiving sugammadex experienced significantly reduced adverse events, highlighting its safety over the traditional neostigmine and atropine regimen.
• Sugammadex demonstrated higher overall efficacy in reversing rocuronium-induced neuromuscular blockade in pediatric populations, suggesting a favorable alternative.