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This is a Quantitative Study study.

September 23, 2025Frontiers in GeneticsOpen Access

Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma

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Systematic analysis reveals mitochondrial gene signature predicts survival in ccRCC, indicating potential for immunotherapy response.

The mitochondrial-related gene signature predicts survival outcomes in clear cell renal cell carcinoma (ccRCC), demonstrating its clinical relevance.
High-risk ccRCC patients based on this gene signature show poorer prognosis and responsiveness to immune checkpoint inhibitors.
Analysis utilized TCGA databases with R tools to evaluate the role of mitochondrial genes and tumor microenvironment in ccRCC.
This novel prognostic model highlights the importance of mitochondrial genes in guiding treatment strategies for ccRCC patients.

Qin et al. (2025) studied this question.

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