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September 23, 2025Frontiers in Pain Research0 citationsOpen Access

NOP Agonist AT-403 Enhances Sleep in Pain Model

NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model

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Authors

BPBethany PierceHMHarlie A. McKelveyMHMary Hunter Hite

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Overview

Experimental analysis reveals NOP agonist AT-403 improves sleep disturbances in pain, suggesting novel analgesic potential.

Key Points

  • NOP agonists, like AT-403, improved sleep duration in acute pain models, unlike traditional analgesics.
  • Lactic acid administration significantly decreased REM and NREM sleep duration in rats, highlighting potential sleep issues.
  • Morphine and meloxicam did not alleviate sleep disturbances induced by lactic acid, underscoring their limitations.
  • AT-403 promoted sleep increase without impairing locomotion, indicating it may be a safer option for managing pain-related sleep issues.

Cite This Study

Pierce et al. (2025) studied this question.

synapsesocial.com/papers/68d4739d31b076d99fa6bbbchttps://doi.org/10.3389/fpain.2025.1659121
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