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Advances and Challenges in Helicobacter pylori Subunit Vaccine Development: Antigen Candidates and Immunization Strategies

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Review discusses immunization strategies and antigen candidates for H. pylori vaccines, indicating strong need for effective solutions.

Subunit vaccines show promising clearance rates for helicobacter pylori in animal models, offering hope for human trials.
Current treatments face issues like antibiotic resistance and costs, highlighting urgent need for effective vaccines.
The UreB vaccine has reached Phase III clinical trials, but no vaccines have been commercialized as of yet.
Key challenges include antigen selection and delivery systems, which must be optimized for effective immunization.

Liu et al. (2025) studied this question.

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