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This is a Cross-Sectional Study study.

September 23, 2025HemaSphereOpen Access

Elevated serum heme oxygenase‐1 in pediatric sickle cell disease: Insights from the SickleGenAfrica Network

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This analysis demonstrates higher serum heme oxygenase-1 levels in children with sickle cell disease, suggesting a role in reducing oxidative stress.

Serum heme oxygenase-1 levels were threefold higher in children under 16 years compared to adults.
In the study of 2309 individuals, median HO-1 levels in children were 69.8 ng/mL, significantly elevated over adult levels of 23.1 ng/mL.
Patients with sickle cell disease had depleted haptoglobin and hemopexin, further emphasizing the role of HO-1 in managing oxidative stress.
The findings point to a crucial protective role of heme oxygenase-1 during childhood in sickle cell disease.

Sowa et al. (2025) studied this question.

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This analysis demonstrates higher serum heme oxygenase-1 levels in children with sickle cell disease, suggesting a role in reducing oxidative stress.