Synthesis of N-CD₃ aryl amines via iron-catalysed site-selective aromatic C–H amination

Q: What type of study is this?

This is a Experimental Study study.

Manman Ren; Yin Yang; Fei Wang

doi:10.1039/d5sc03780h

January 1, 2025Chemical ScienceOpen Access

Synthesis of N-CD₃ aryl amines via iron-catalysed site-selective aromatic C–H amination

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Key Points

The iron-catalysed protocol achieves site-selective aromatic C–H amination effectively, enhancing synthetic strategies.
Key intermediate, the iron-aminyl radical, facilitates the process through unique homolytic aromatic substitution.
Involvement of basic functional groups is crucial for the chelation that drives the reaction mechanism.
This approach supports new avenues in designing selective C–H functionalization reactions for various applications.

Implication

Iron-catalysed method demonstrates efficient site-selective C–H amination in arylamines, indicating a novel mechanism.

Abstract

An iron-catalysed protocol for site-selective aromatic C–H N-CD 3 amination is reported. The iron-aminyl radical is proposed as the key intermediate that facilitates homolytic aromatic substitution through chelation with basic functional groups.

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Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/68d473ad31b076d99fa6c300 https://doi.org/10.1039/d5sc03780h

View Full Paper

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Synthesis of N-CD₃ aryl amines via iron-catalysed site-selective aromatic C–H amination

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of N-CD₃ aryl amines via iron-catalysed site-selective aromatic C–H amination

Key Points

Implication

Abstract

Discussion

Cite This Study

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