Iron-catalyzed azidation produces γ-selective products from hydroxylamine derivatives, suggesting a new synthetic route.
We report an iron-catalyzed intermolecular C(sp³)-H azidation that proceeds with exclusive γ-selectivity relative to the carbonyl group via a 1,5-hydrogen atom transfer process initiated by an iron-nitrenoid species. This strategy, based on the combination of hydroxylamine derivatives and trimethylsilyl azide with a simple iron catalyst, provides efficient access to a broad range of azido-amide and azido-carbamate products.
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Esteves et al. (2026) studied this question.
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