An efficient method for remote radical C(sp3)–H azidation at unactivated sites is described. C–H functionalization proceeds via intramolecular 1,5-hydrogen atom transfer to N-centered radicals that are generated via azido group transfer and/or fragmentation. The readily installed sulfamoyl azide serves as both an amidyl radical precursor and an azido source. This reaction features excellent site selectivity for tertiary, secondary, primary, and benzylic C(sp3)–H bonds and exhibits broad functional group compatibility.
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Li et al. (2024) studied this question.
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