Experimental approaches demonstrate improved catalytic efficiency in C-H functionalization with mechanistic insights.
-benzyl azoles. Finally, we discuss our deep mechanistic interrogation of C-H sulfonamidation, where the identification and suppression of a parasitic proton-coupled electron transfer (PCET) pathway proved essential for catalytic efficiency.Collectively, these studies demonstrate that with the correct polarity-inversion machinery, C-H bonds can be viewed not merely as radical precursors, but as latent carbocations ready to engage in the full spectrum of polar reactivity.
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Mortimer et al. (2026) studied this question.
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