Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones

Vaibhav Ramachandra Pansare; Sreelakshmi N; Priyam Bajpai

doi:10.1039/d6qo00044d

January 1, 2026Organic Chemistry Frontiers

Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones

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Key Points

The aim is to explore the direct C–H alkylation of nitrogen-containing heterocycles for pharmaceutical applications.
Utilized iron-catalyzed reactions for C–H alkylation
Focused on pyrazinones, azauracils, and quinoxalinones
Investigated site-selectivity in alkylation processes
Successfully achieved site-selective alkylation in specified heterocycles
Demonstrated the efficiency of iron as a catalyst in these transformations
Highlighted potential applications in developing new pharmaceutical compounds

Implication

Demonstrates site-selective C-H alkylation in nitrogen-containing heterocycles, indicating significant pharmaceutical potential.

Abstract

The direct C–H alkylation of nitrogen-containing heterocycles is a valuable and widely pursued transformation due to the importance of these scaffolds in pharmaceuticals and bioactive natural products. In this study,...

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Cite This Study

Pansare et al. (2026) studied this question.

synapsesocial.com/papers/69a91da8d6127c7a504c09ee https://doi.org/10.1039/d6qo00044d

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Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Site-selective iron-catalyzed C-H alkylation of pyrazinones, azauracils and quinoxalinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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