Azirine-Enabled Regioselective Synthesis of N-Alkyl Pyrazoles and Indole–Pyrazole Conjugates via Cu-Catalysed N–N Bond Formation

Q: What does this research mean for the field?

Azirine-2H-carbaldehydes serve as effective building blocks for the regioselective synthesis of aliphatic N-substituted pyrazoles and indole-pyrazole conjugates via copper-catalyzed N-N bond formation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

A. Chaturvedi; Vishal Sharma; Pankaj Sharma; Manpreet Singh; C. Malakar; Ravindra K. Rawal; Virender Singh

doi:10.1039/d6ob00123h

January 1, 2026Organic & Biomolecular Chemistry

Azirine-Enabled Regioselective Synthesis of N-Alkyl Pyrazoles and Indole–Pyrazole Conjugates via Cu-Catalysed N–N Bond Formation

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Key Points

This research aims to develop a sustainable method for synthesizing aliphatic N-substituted pyrazoles using azirine derivatives.
Developed a strategy for regioselective synthesis using azirine-2H-carbaldehydes.
Utilized copper catalysis to facilitate N–N bond formation.
Explored the versatility of azirine derivatives as building blocks.
Successfully synthesized a new class of aliphatic N-substituted pyrazoles with high regioselectivity.
Demonstrated the efficiency of the method through various reactions yielding significant product diversity.
Highlighted the sustainability of the process relevant to green chemistry practices.

Implication

Demonstrates regioselective synthesis of pyrazoles in aliphatic compounds, indicating a sustainable method.

Abstract

An efficient and sustainable strategy has been developed for the regioselective synthesis of a new class of aliphatic N-substituted pyrazoles using azirine-2H-carbaldehydes as versatile building blocks. The transformation proceeds via...

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Cite This Study

Chaturvedi et al. (2026) studied this question.

synapsesocial.com/papers/6a0aad015ba8ef6d83b7079c https://doi.org/10.1039/d6ob00123h

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Azirine-Enabled Regioselective Synthesis of N-Alkyl Pyrazoles and Indole–Pyrazole Conjugates via Cu-Catalysed N–N Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

Azirine-Enabled Regioselective Synthesis of N-Alkyl Pyrazoles and Indole–Pyrazole Conjugates via Cu-Catalysed N–N Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

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