Efficient Cu(I)-catalyzed alkynylation yields N,N′-bicyclic pyrazolidinones, suggesting a novel synthetic strategy.
An efficient Cu(I)-catalyzed interrupted CuAIAC/alkynylation cascade reaction has been developed for the preparation of alkynyl N,N′-bicyclic pyrazolidinones utilizing various alkynes, azomethine imines, and bromoalkynes. This method exhibits excellent regioselectivity and good functional group tolerance. In addition, the complex molecule-derived alkyne and bromoalkyne substrates are compatible with the reaction system and make it a highly efficient synthetic strategy.
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Wang et al. (2026) studied this question.
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