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September 23, 2025European Journal of Medicinal PlantsOpen Access

Formulation Development and Optimization of Polyherbal Gastro-retentive Floating Tablets Using Central Composite Design

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Authors

SSSatyajit SahooPPPrasanna Kumar PradhanAKArchana Kaushik

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Overview

Experimental design optimizes drug release and floating time in polyherbal gastro-retentive tablets, indicating effective formulation strategies.

Key Points

  • The formulation achieved a floating lag time of less than 1 minute and a total floating time exceeding 8 hours.
  • Percentage cumulative drug release across formulations ranged from 65% to 95%, highlighting effective release profiles.
  • Direct compression was utilized for tablet preparation, with central composite design optimizing polymer concentrations.
  • Results indicate that experimental design successfully enhanced the formulation with fewer trials and improved quality.

Cite This Study

Sahoo et al. (2025) studied this question.

synapsesocial.com/papers/68d473ad31b076d99fa6c4d4https://doi.org/10.9734/ejmp/2025/v36i51293
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