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Study developed and evaluated a polyherbal effervescent tablet for digestive support, indicating improved patient compliance.
ABSTRACTBackground: Gastrointestinal disorders such as dyspepsia, flatulence, bloating, constipation, and indigestion areamong the most prevalent digestive ailments worldwide. Although conventional medicines provide symptomaticrelief, prolonged use is often associated with adverse effects and poor patient compliance. Herbal medicines havegained considerable attention due to their safety, efficacy, and holistic therapeutic benefits. Incorporating herbalextracts into effervescent tablet formulations offers rapid drug release, improved palatability, enhanced patientcompliance, and better bioavailability.Objective: The present study aimed to formulate and evaluate a novel polyherbal effervescent tablet containingselected medicinal herbs possessing digestive stimulant, carminative, antispasmodic, antioxidant, andgastroprotective activities.Materials and Methods: Polyherbal effervescent tablets were prepared by direct compression using standardizedherbal powders of Trachyspermumammi, Menthaarvensis, Foeniculumvulgare, Zingiberofficinale,Cuminumcyminum, Camellia sinensis, and Glycyrrhizaglabra. Seven formulations (F1–F7) were developed usingvarying concentrations of citric acid, sodium bicarbonate, binder, and excipients. The prepared formulations wereevaluated for pre-compression parameters including angle of repose, bulk density, tapped density, Carr's index,and Hausner ratio. Post-compression studies included weight variation, hardness, friability, effervescence time,solution pH, and tablet appearance.Results: Among all formulations, F3 demonstrated superior pharmaceutical characteristics. The optimizedformulation exhibited an angle of repose of 27.5°, Carr's index of 17.2%, Hausner ratio of 1.21, hardness of 3.2kg/cm², friability of 0.42%, effervescence time of 2.2 minutes, and solution pH of 6.2. The formulation possessedacceptable mechanical strength, rapid dispersion, pleasant taste, and excellent patient acceptability.Conclusion: The developed polyherbal effervescent tablet represents a promising natural dosage form fordigestive support. The combination of medicinal herbs with effervescent technology improved tabletperformance, rapid drug release, and patient compliance. Further pharmacological, stability, and clinicalinvestigations are warranted to establish its therapeutic efficacy and commercial applicability.
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P. Ruchitha, PK. Preethi Pooja, S. Anuradha Bai, P. Ravi Kumar (2026) studied this question.