Previous title: Inhibition of ex vivo VEGF-induced angiogenesis by tyrosol and hydroxytyrosol present in Mediterranean diet foods: Quantitative three-dimensional mouse aortic ring model Current version title: Inhibition of ex vivo VEGF-induced angiogenesis by tyrosol and hydroxytyrosol: Quantitative three-dimensional mouse aortic ring mode

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This is a Quantitative Study study.

Ana B. Cerezo; Marta Gallardo Fernández; Álvaro Santana‐Garrido; Ruth Hornedo‐Ortega; Carmen M. Vázquez; Ana M. Troncoso; M. Carmen García-Parrilla

doi:10.1039/d5fo02820e

January 1, 2025Food & FunctionOpen Access

Previous title: Inhibition of ex vivo VEGF-induced angiogenesis by tyrosol and hydroxytyrosol present in Mediterranean diet foods: Quantitative three-dimensional mouse aortic ring model Current version title: Inhibition of ex vivo VEGF-induced angiogenesis by tyrosol and hydroxytyrosol: Quantitative three-dimensional mouse aortic ring mode

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Key Points

Inhibition of VEGF-induced angiogenesis was observed with tyrosol and hydroxytyrosol in mouse aortic rings, indicating potential therapeutic effects.
A quantitative analysis using a three-dimensional model revealed significant antiangiogenic properties of bioactive compounds from Mediterranean foods.
The methodology employed a mouse aortic ring model to assess the effects of tyrosol and hydroxytyrosol on angiogenesis induced by VEGF.
These findings suggest that compounds in the Mediterranean diet may provide beneficial effects against conditions related to excessive angiogenesis.

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Implication

Quantitative model demonstrates inhibition of VEGF-induced angiogenesis by tyrosol and hydroxytyrosol, highlighting Mediterranean diet benefits.

Abstract

Mediterranean diet foods such as olives, virgin olive oil and wine are sources of tyrosol (TOL) and hydroxytyrosol (HT) bioactive compounds. HT has already shown in vitro antiangiogenic effects in...

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Cerezo et al. (2025) studied this question.

synapsesocial.com/papers/68d473ad31b076d99fa6c514 https://doi.org/10.1039/d5fo02820e

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