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September 23, 2025Applied SciencesOpen Access

Exploring Protein Misfolding and Aggregate Pathology in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Interventions

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Authors

JJJane E. JohnsonSouthwestern Medical CenterFAFila Winifred AwosiminialaFederal University OtuokeCAChristian AnumuduFederal University Otuoke

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Implication

This review explores the role of protein aggregation in neurodegenerative diseases, highlighting therapeutic strategies and implicating sex differences and age-related factors.

Key Points

  • Neurodegenerative diseases demonstrate progressive neuronal loss primarily driven by protein aggregation, which disrupts cellular functions.
  • Key proteins involved in aggregation, such as tau and alpha-synuclein, exacerbate neuroinflammation and mitochondrial dysfunction.
  • Current strategies aimed at restoring proteostasis include immunotherapy and enhancing protein clearance pathways in clinical settings.
  • Advancements in single-cell transcriptomics provide insights into disease mechanisms, supporting precision medicine approaches in treatment.

Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/68d473b531b076d99fa6c62fhttps://doi.org/10.3390/app151810285
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apolipoprotein E4 genotype compromises brain exosome production2018 · 111 citations
  2. 2Single-Cell Sequencing in Neurodegenerative Disorders2023 · 28 citations