Observational analysis of erg11, mdr1, and cdr1 expression in Candida albicans isolates, suggesting insights into azole resistance mechanisms.
Introduction Candida albicans is an opportunistic pathogen linked to severe, often fatal, infections. Azoles are the first line of treatment, but its resistance has increasingly been reported worldwide. Azole resistance mechanisms involve the overexpression and mutations of genes such as ERG11, MDR1, and CDR1. Our research is focused on comprehending the baseline expression of azole resistance-related genes to monitoring the prevalence of drug resistance within Ecuador.
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Sánchez-Villacreses et al. (2025) studied this question.
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