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This is a Cross-Sectional Study study.

Biomarkers for Alzheimer's disease are upregulated in patients with diabetic retinopathy

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Prospective analysis shows elevated Alzheimer's biomarkers in plasma of diabetic retinopathy patients, suggesting a potential link.

Significant increases in Alzheimer's disease biomarkers were observed in plasma of diabetic retinopathy patients.
Participants with diabetic retinopathy had elevated levels of total-tau, phosphorylated-tau, and neurofilament light chain in ocular fluids.
Neuropsychological scores were lower in diabetic retinopathy patients, though results were not statistically significant.
The findings suggest diabetic retinopathy may serve as an indicator for Alzheimer's disease pathology.

Subramanian et al. (2025) studied this question.

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