Effect of Septoplasty Surgery on Serum Prolidase Enzyme Activity Levels

Abstract Objective In this study, we aimed to compare the serum prolidase enzyme activity (SPEA) levels between patients with nasal septum deviation (NSD) and the control group, and also to determine the effects of septoplasty surgery on SPEA levels in the patient group. Materials and Methods Serum SPEA levels were compared between the study group consisting of 35 patients and the control group consisting of 35 patients. Preoperative and postoperative SPEA levels were also compared in the patient group. Results The mean SPEA value was 214.77 ± 31.13 U/L preoperative group and 184.87 ± 27.68 U/L postoperative group. The decrease in SPEA levels after the septoplasty was statistically significant (p < 0.05). When the patient and control groups were compared, SPEA levels in the patient group were statistically significantly higher than in the control group (p < 0.05). The mean SPEA value was 179.48 ± 15.48 U/L in the control group, whereas it was 214.77 ± 31.13 U/L in the patient group. Conclusions We found that SPEA levels were statistically significantly higher in patients with NSD compared to healthy individuals. Furthermore, a significant decrease in SPEA levels was detected after septoplasty in the patient group.These findings suggest that prolidase may be a powerful enzyme in the etiopathogenesis of NSD and may be a marker of clinical recovery.